| Title |
The post-abscission midbody is an intracellular signaling organelle that regulates cell proliferation / |
| Authors |
Peterman, Eric ; Gibieža, Paulius ; Schafer, Johnathon ; Skeberdis, Vytenis Arvydas ; Kaupinis, Algirdas ; Valius, Mindaugas ; Heiligenstein, Xavier ; Hurbain, Ilse ; Raposo, Graca ; Prekeris, Rytis |
| DOI |
10.1038/s41467-019-10871-0 |
| Full Text |
|
| Is Part of |
Nature Communications.. London : Nature Publishing Group. 2019, vol. 10, no. 1, 3181, p. 981-988.. ISSN 2041-1723. eISSN 2041-1723 |
| Abstract [eng] |
Once thought to be a remnant of cell division, the midbody (MB) has recently been shown to have roles beyond its primary function of orchestrating abscission. Despite the emerging roles of post-abscission MBs, how MBs accumulate in the cytoplasm and signal to regulate cellular functions remains unknown. Here, we show that extracellular post-abscission MBs can be internalized by interphase cells, where they reside in the cytoplasm as a membrane-bound signaling structure that we have named the MBsome. We demonstrate that MBsomes stimulate cell proliferation and that MBsome formation is a phagocytosis-like process that depends on a phosphatidylserine/integrin complex, driven by actin-rich membrane protrusions. Finally, we show that MBsomes rely on dynamic actin coats to slow lysosomal degradation and propagate their signaling function. In summary, MBsomes may sometimes serve as intracellular organelles that signal via integrin and EGFR-dependent pathways to promote cell proliferation and anchorage-independent growth and survival. |
| Published |
London : Nature Publishing Group |
| Type |
Journal article |
| Language |
English |
| Publication date |
2019 |
