| Title |
The roles of carbonic anhydrases IX and XII in cancer cell adhesion, migration, invasion and metastasis / |
| Authors |
Daunys, Simonas ; Petrikaitė, Vilma |
| DOI |
10.1111/boc.201900099 |
| Full Text |
|
| Is Part of |
Biology of the cell.. Hoboken : Wiley. 2020, vol. 112, no. 12, p. 383-397.. ISSN 0248-4900. eISSN 1768-322X |
| Keywords [eng] |
CA IX ; CA XII ; cell adhesion ; cell invasion ; cell migration ; metastasis |
| Abstract [eng] |
The main function of carbonic anhydrases (CAs) in cancer cells is the pH regulation through a conversion of H2 O and CO2 to H+ and HCO3 - . However, the data of in vitro and in vivo studies have demonstrated that transmembrane isoforms of CA IX and CA XII are involved in various steps of cancer cell migration, invasion and metastasis. According to literature, inhibition of these CAs can affect the expression of multiple proteins. Some scientific groups have reported the possible interactions between CA IX and E-cadherin-catenin system, CA IX and integrins, CA IX, CA XII and ion transporters, which all are highly involved in cell-to-cell adhesion, the formation of membrane protrusions and focal adhesions. Nevertheless, CA IX and CA XII have a high impact on tumor growth and metastases formation. The data discussed in this review highly supports the role of both transmembrane CAs in various cancer metastasis processes through interactions between CAs and other invasion proteins. Nevertheless, the exact mechanisms of these interactions are not yet determined and need further investigation. This article is protected by copyright. |
| Published |
Hoboken : Wiley |
| Type |
Journal article |
| Language |
English |
| Publication date |
2020 |
