| Abstract [eng] |
Background: To report the incidence of retinopathy of prematurity (ROP) at Cipto Mangunkusumo Hospital, Indonesia, and its relation to several risk factors. The results of treatment are also reported. Materials and Methods: A hospital-based prospective-cohort study in 33 infants in the neonatology ward of Cipto Mangunkusumo Hospital, Jakarta, Indonesia, who were referred for ROP screening from December 2003 to December 2004 was performed. Risk factors such as gestational age (GA) at birth ≤ 32 weeks, birth weight (BW) ≤ 1500 g, duration of oxygen (O2) therapy more than 7 days, gender, birth status, the presence of clinical sepsis, respiratory distress syndrome (RDS), apnea, asphyxia, and maternal pre-eclampsia / eclampsia were analyzed using the chi-square test and multivariate analysis. Results: Of the total of 33 cases, ROP at any stage of disease was found in 30.3%. Infants with ROP were significantly smaller (mean ± SD of 1397 ± 153.5 g vs. 1610 ± 218.8 g, p = 0.009), but not significantly younger (mean ± SD of 31.7 ± 2 weeks vs. 33.3 ± 2 weeks, p = 0.058) than infants without ROP. Logistic regression showed that low birth weight was not a significant risk-factor for ROP. Asphyxia was found to be the only significant risk factor for the occurrence of ROP (p = 0.021, OR = 13.525). Laser photocoagulation or cryotherapy was performed in 2 out of 3 threshold ROP cases, but the outcomes were still unsatisfactory. Conclusions: Our results are similar to those reported from previous studies in other developing countries, although in this study young gestational age and low birth weight were not associated with the risk of ROP. Further studies in a larger sample are required to confirm these findings and to establish effective screening guidelines. |
