Title Correlation among decreased regional cerebral oxygen saturation, blood levels of brain injury biomarkers, and cognitive disorder :
Authors Kumpaitiene, Birute ; Svagzdoeme, Milda ; Drigotiene, Ingrida ; Sirvinskas, Edmundas ; Sepetiene, Ramune ; Zakelis, Rolandas ; Benetis, Rimantas
DOI 10.1177/0300060518776545
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Is Part of Journal of international medical research.. London : Sage Publications. 2018, vol. 46, iss. 9, p. 3621-3629.. ISSN 0300-0605. eISSN 1473-2300
Keywords [eng] cardiac surgical procedures ; cardiopulmonary bypass ; postoperative complications ; cerebrovascular circulation ; cognition ; oxygen ; biomarkers
Abstract [eng] Objective This study was performed to investigate the correlation among decreased regional cerebral oxygen saturation (rSO2), blood levels of brain injury biomarkers, and postoperative cognitive disorder (POCD) after cardiac surgery with cardiopulmonary bypass (CPB). Methods This prospective observational study included 59 patients undergoing coronary artery bypass graft surgery with CPB. All patients underwent neuropsychological tests (Mini Mental State Evaluation, Rey Auditory Verbal Learning Test, digit span test, digit symbol substitution test, and Schulte table) the day before and 10 days after the surgery. The blood levels of two brain injury biomarkers, neuron-specific enolase (NSE) and glial fibrillary acidic protein (GFAP), were measured before and 1 day after the surgery. Results The rSO2 decreased during surgery in 21 (35%) patients. POCD was detected in 22 (37%) patients. After the surgery, no significant changes in the GFAP blood level occurred in any patients. No significant correlations were found among the decreased rSO2, increased NSE blood level, and rate of POCD. Conclusion These results suggest that a decrease in rSO2 during cardiac surgery is not necessarily related to the development of POCD or an increased blood level of the brain injury biomarker NSE.
Published London : Sage Publications
Type Journal article
Language English
Publication date 2018
CC license CC license description